CURRICULUM VITAE
 | Dr. E.K. Arkenbout Arts-assistent cardiologie Academisch Medisch Centrum, Amsterdam |
EDUCATION and EMPLOYMENT HISTORY
High School: VWO, Blaise Pascal, Spijkenisse
University: 1990: propedeuse Biology, Vrije Universiteit Amsterdam
1993: propedeuse Medical School, Vrije Universiteit Amsterdam
1995: Masters degree Medical School,Vrije Universiteit Amsterdam
1997: Masters degree Medical Biology,Vrije Universiteit Amsterdam
Post-Doctoral Training:
1998-2004 PhD thesis: Department of Medical Biochemistry AMC (Molecular
Cardiology Program,The Netherlands Heart Foundation)
Project: “Nuclear receptors of the NGFI-B subfamily of steroid/thyroid hormone receptors involved in Smooth Muscle Cell proliferation in atherosclerosis: specific inhibition by dominant-negative variants in mouse-models”.
PhD degree September 9th 2004
2002: Initiation specialty training Cardiology, AMC, Amsterdam, Tutor Prof dr RBA van den Brink
2002-2004 Internal Medicine, OLVG, Amsterdam, Tutor Prof dr P.H.J. Frissen
2004-2007 Cardiology training, AMC, Amsterdam, Tutor Prof dr R.B.A. van den Brink
2007 postdoctoral fellow, Johns Hopkins University, Baltimore, USA
2008-2009 Cardiology training, AMC, Amsterdam, Tutor Prof dr R.B.A. van den Brink
RESEARCH INTERNATIONAL
1995 University Hospital, Kuopio, Finland (1 month):
Elective in Intensive Care Medicine, Intensive Care Unit
Dr. J. Takara
1997 Yeovil District Hospital, “keuzecoschap” Internal Medicine
Higher Kingston, Yeovil, Somerset, Engeland
Dr. T.G. Palferman
1998 Training in carotid artery ligation at the lab of Dr. V. Lindner, Portland, Maine, USA
2007 postdoctoral fellow
Johns Hopkins University, Baltimore, USA
Dr J.J. Rade
AWARDS and FELLOWSHIPS
2000 Young Investigator Award. First Congress on Atherosclerosis Thrombosis and Vascular Biology, Denver, USA.
2004 EVBA Travel Bursary. International Vascular Biology Meeting, Toronto, Canada
2007 Dekker fellowship Dutch Heart Foundation “arts in opleiding tot specialist"
CONFERENCES ATTENDED
1999 Keystone symposium on Inflammatory Paradigms and the Vasculature,
Santa Fe, USA
"Nuclear orphan receptors TR3 orphan receptor, MINOR and NOT involved in human atherogenesis". (poster)
Masterclass Prof.R.D.Rosenberg, AMC, Amsterdam, The Netherlands
"Novel ‘atherosclerotic’ genes in smooth muscle cells / ‘early’ transcription factor TR3". (oral presentation)
Ned. Ver. Thrombose Haemostase Najaarsdag, AMC, Amsterdam, The Netherlands
“Nuclear Hormone receptors TR3, MINOR and NOT involved in human atherogenesis". (oral presentation)
2000 First Congress on Atherosclerosis Thrombosis and Vascular Biology,
Denver, USA
"The NGFI-B subfamily of steroid/thyroid hormone receptors involved in SMC proliferation in atherogenesis". (poster, Young Investigator Award)
XXIInd congress of the European Society of Cardiology (ESC), Amsterdam, The Netherlands
"A subfamily of steroid/thyroid hormone receptors, identified in an Differential Display RT/PCR based analysis, are involved in atherogenesis". (oral presentation)
XIth International Vascular Biology Meeting, Geneva, Zwitserland
"Steroid/thyroid hormone nuclear receptors of the NGFI-B subfamily expressed in neointimal smooth muscle cells; a potential function in human atherogenesis". (poster)
2001 Dutch Atherosclerosis Society, Ermelo, The Netherlands
Steroid/thyroid hormone nuclear receptors of the NGFI-B subfamily expressed in human atherosclerotic lesions; a potential function in human atherogenesis". (poster)
Second Annual Conference on Atherosclerosis Thrombosis and Vascular Biology
"Orphan nuclear receptors expressed in human atherosclerotic lesions". (poster), Washington DC, USA
2002 Dutch Atherosclerosis Society, Ermelo, The Netherlands
“Orphan nuclear receptors of the NGFI-B subfamily diminish vascular lesion formation in vivo dramatically: functional involvement in atherogenesis”. (oral presentation)
Third Annual Conference on Atherosclerosis Thrombosis and Vascular Biology, Salt Lake City, USA
“Orphan nuclear receptors of the NGFI-B subfamily diminish vascular lesion formation in vivo dramatically: functional involvement in atherogenesis”. (oral presentation)
2004 International Vascular Biology Meeting, Toronto, Canada
“TR3 nuclear orphan receptor is induced in in-stent restenosis and modulates expression of cell cycle genes and adrenomedullin” (poster, EVBA travel bursary to attend IVBM)
2006 American Heart Association scientific sessions 2006 (AHA), Chicago, USA
2007 American Heart Association scientific sessions 2007 (AHA), Orlando, USA
2008 Cold Spring Harbor Laboratory, Nuclear receptors: bench to bedside, New York, USA
OTHER
Reviewer grant proposals Netherlands Heart Foundation
Supervision of post-doc appointed to the Dekker fellowship Dutch Heart Foundation “arts in opleiding tot specialist": “Nuclear receptor Nur77 in acute and chronic heart failure”
PUBLICATIONS
Monajemi H, Arkenbout EK and Pannekoek H. Gene expression in atherogenesis.
Thrombosis and Hemostasis. 2001; 86: 404-412
Arkenbout EK, de Waard V, van Bragt M, van Achterberg TAE, Grimbergen JM, Pichon B, Pannekoek H and de Vries CJM: Protective function of transcription factor TR3 orphan receptor in atherogenesis: Decreased lesion formation in carotid artery ligation model in TR3 transgenic mice.
Circulation. 2002;106: 1530-1535
de Waard, V, Arkenbout, EK, Carmeliet, P, Lindner V, and Pannekoek, H.: Plasminogen activator inhibitor 1 and vitronectin protect against restenosis in a murine carotid artery ligation model.
Arterioscler Thromb Vasc Biol. 2002;22:1978-83.
Engelse MA, Arkenbout EK, Pannekoek H, de Vries CJ. Activin and TR3 orphan receptor: two 'atheroprotective' genes as evidenced in dedicated mouse models.
Clin Exp Pharmacol Physiol. 2003;30:894-9.
Arkenbout EK, Dekker RJ, de Vries CJ, Horrevoets AJ, Pannekoek H.Focusing on transcription factor families in atherogenesis: the function of LKLF and TR3.
Thromb Haemost. 2003;89:522-9.
Arkenbout EK, van Bragt M, Eldering E, van Bree C, Grimbergen JM, Quax PH, Pannekoek H, de Vries CJ.TR3 orphan receptor is expressed in vascular endothelial cells and mediates cell cycle arrest.
Arterioscler Thromb Vasc Biol. 2003;23:1535-40.
De Waard V, Arkenbout EK, Vos M, Mocking AI, Niessen HW, Stooker, de Mol BA, Quax PH, Bakker EN, Van Bavel E, Pannekoek H, de Vries CJ. TR3 nuclear orphan receptor prevents cyclic stretch-induced proliferation of venous smooth muscle cells.
Am J Pathol. 2006;168:2027-35.
Bonta PI, van Tiel CM, Vos M, van Thienen JH, Ferreira V, Arkenbout EK, Seppen J, Spek CA, van der Poll T, Pannekoek H, de Vries CJM. Nuclear receptors Nur77, Nurr1 en NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arterioscler Thromb Vasc Biol. 2006 Oct;26:2288-94
Pires NM, Pols TW, de Vries MR, van Tiel CM, Bonta PI, Vos M, Arkenbout EK, Pannekoek H, Jukema JW, Quax PH, de Vries CJM. Activation of nuclear receptor Nur77 by 6MP protects against neointima formation. Circulation. 2007 Jan 30:493-500.
Published abstracts
De Waard, Arkenbout EK, Carmeliet P, et al. Vitronectin and plasminogen activator inhibitor-1 protect against stenosis in the murine carotid artery ligation model. Fibrinolysis & Proteolysis 14:O4 Suppl 2000
Arkenbout EK, et al. Steroid/thyroid hormone nuclear receptors of the NGFI-B subfamily expressed in neointimal smooth muscle cells; a potential function in human atherogenesis. J. Submicrosc. Cytol. and Pathol. Vol 32 (3): July 2000: 445
Arkenbout EK, et al. A subfamily of steroid/thyroid hormone receptors, identified in an Differential Display RT/PCR based analysis, are involved in atherogenesis. European Heart Journal Vol 21: August/September 2000: 482
Arkenbout EK, de Waard V, van Bragt M, et al. Decreased vascular lesion formation in TR3 orphan receptor transgenic mice: preliminary inventory on changes in physioloy of the aorta. Clinical and experimental Pharmacology and Physiology 29 (8): A96-A96 aug 2000
Arkenbout EK, de Waard V, van Bragt M, et al. A dominant-negative variant of nuclear receptor TR3 aggravates vascular lesion formation. Arteriosclerosis Thrombosis and Vascular Biology 22 (5): P260 may 2002
Arkenbout EK, de Waard V, van Bragt M, et al. Expression of the atheroprotective TR3 nuclear orphan receptor in human atherosclerosis and in-stent restenosis. European Heart Journal 24: 668-668 suppl S aug-sep 2003
De Waard V, Arkenbout EK, Mocking AIM, et al. TR3 orphan receptor involved in vein-graft disease. Cardiovascular pathology 13: P551 Suppl. May/Jun 2004
Arkenbout EK, de Waard V, van Bragt M, et al. TR3 nuclear orphan receptor is induced in in-stent restenosis and modulates expression of cell-cycle genes and adrenomedullin. Cardiovascular pathology 13:P080 Suppl. May/June 2004